4917 Waters Edge Drive, Suite 275
Raleigh, NC 27606
2 Davis Drive
Durham, NC 27709
101 North Chestnut Street, Suite 103
Winston-Salem, NC 27101
The materials science patents group is international in scope, seeking patent protection on behalf of clients in many foreign jurisdictions. Additionally, the patent practice advises clients on freedom to operate analysis and clearance for entry of new products into the United States and foreign countries, as well in due diligence matters for intellectual property acquisition and monetization. The materials science team has worked with technologies including nanostars and gold rods for imaging in medical sciences, chip and semiconductor design, and chemicals for use in processing and industrial facilities.
A dielectric material is provided. The dielectric material includes at least one layer of a substantially continuous phase material. The material is selected from the group consisting of an organic, organometallic, or combination thereof in which the substantially continuous phase material has delocalized electrons.
A polymer-free synthesis method is provided for preparation of monodisperse nanostars. The nanostars can be used for treating and imaging cells in in vivo or ex vivo. The modes of treatment include use of a nanostar modified with a photo-activatable drug, which drug is activated by the photo-response of the nanostar to electromagnetic stimulation; use of a nanostar modified with a thermally-activatable drug, which drug is activated by a thermal response of the nanostar to electromagnetic stimulation; and the thermal response of the nanostar itself to electromagnetic stimulation, which can directly or indirectly cause the death of an undesirable cell.
Plasmonics-active nanoprobes are provided for detection of target biomolecules including nucleic acids, proteins, and small molecules. The nucleic acids that can be detected include RNA, DNA, mRNA, microRNA, and small nucleotide polymorphisms (SNPs). The nanoproprobes can be used in vito in sensitive detection methods for diagnosis of diseases and disorders including cancer. Multiplexing can be performed using the nanoprobes such that multiple targets can be detected simultaneously in a single sample. The methods of use of the nanoprobes include detection by a visible color change. The nanoprobes can be used in vivo for treatment of undesireable cells in a subject.